Full Name: Alcohol Dehydrogenase 1C
Genomic Location: Chromosome 4:99,336,492-99,353,045
Protein Size: 375 amino acids
This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster.
There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.
- rs698 is linked to ADH1C, it is located within the coding region of the gene.
- Population frequencies are approximately 65% for the reference allele (A) and 35% for the alternate allele (G).
- Studies suggest the G allele is associated with an increased sensitivity to alcohol.