Full Name: Adrenoceptor Beta 3
Genomic Location: Chromosome 8:37,962,990-37,966,666
Protein Size: 408 amino acids
The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis.
- rs4994 is linked to ADRB3, it is located within the coding region of the gene.
- Population frequencies are approximately 90% for the reference allele (T) and 10% for the alternate allele (C).
- Studies suggest the C allele is associated with endurance sports and reduced risk from obesity when exercising and following a healthy diet.