Full Name: Adrenoceptor Beta 3

Genomic Location: Chromosome 8:37,962,990-37,966,666 

Protein Size: 408 amino acids


The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. 

Linked SNP(s):

  • rs4994 is linked to ADRB3, it is located within the coding region of the gene.
  • Population frequencies are approximately 90% for the reference allele (T) and 10% for the alternate allele (C).
  • Studies suggest the C allele is associated with endurance sports and reduced risk from obesity when exercising and following a healthy diet.
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