Full Name: Angiotensin II Receptor Type 1

Genomic Location: Chromosome 3:148,697,784-148,743,008

Protein Size: 359 amino acids


Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium.

Linked SNP(s):

  • rs5186 is linked to AGTR1, it is located within the coding region of the gene.
  • Population frequencies are approximately 78% for the reference allele (A) and 22% for the alternate allele (C).
  • Studies suggest the C allele is associated with an increased risk for metabolic syndrome that can be mitigated through a healthy diet.
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