Full Name: Apolipoprotein A2
Genomic Location: Chromosome 1:161,222,292-161,223,631
Protein Size: 100 amino acids
This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
- rs5082 is linked to APOA2, it is located approximately 300 bases downstream.
- Population frequencies are approximately 33% for the reference allele (C) and 67% for the alternate allele (T).
- Studies suggest the C allele is associated with a sensitivity to bad fats.