FTO

Full Name: FTO Alpha-Ketoglutarate Dependent Dioxygenase

Genomic Location: Chromosome 16:53,701,692-54,158,512

Protein Size: 505 amino acids

Function:

This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.

Linked SNP(s):

  • rs8044769 is linked to FTO, it is located within an intron.
  • Population frequencies are approximately 40% for the reference allele (T) and 60% for the alternate allele (C).
  • Studies suggest the C allele is associated with a higher positive affect after 30 minutes of physical exercise.
  • rs1421085 is linked to FTO, it is located within an intron.
  • Population frequencies are approximately 68% for the reference allele (T) and 32% for the alternate allele (C).
  • Studies suggest the C allele is associated with an increased risk for obesity that can be addressed through dieting and physical exercise.
  • rs9939609 is linked to FTO, it is located within an intron.
  • Population frequencies are approximately 58% for the reference allele (T) and 42% for the alternate allele (A).
  • Studies suggest the A allele is associated with an increased risk for obesity that can be addressed through dieting.
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