Full Name: Fucosyltransferase 2
Genomic Location: Chromosome 19:48,695,971-48,705,950
Protein Size: 343 amino acids
Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids. The resulting epitope plays a role in cell-cell interaction including host-microbe interaction. Mediates interaction with intestinal microbiota influencing its composition. Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway.
There are two genes (FUT1 and FUT2) which encode galactoside 2-L-fucosyltransferase. They are expressed in a tissue-specific manner with expression restricted to cells of mesodermal or endodermal origin respectively.
- rs602662 is linked to FUT2, it is located within the coding region.
- Population frequencies are approximately 59% for the reference allele (G) and 41% for the alternate allele (A).
- Studies suggest the G allele is associated with reduced vitamin B12 levels.