GSTP1

Full Name: Glutathione S-Transferase Pi 1

Genomic Location: Chromosome 11:67,583,595-67,586,65 

Protein Size: 210 amino acids

Function:

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalysing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorised into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.

Linked SNP(s):

  • rs1695 is linked to GSTP1, it is located within the coding region.
  • Population frequencies are approximately 66% for the reference allele (A) and 34% for the alternate allele (G).
  • Studies suggest the G allele is associated with a higher level of aerobic response to training.
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