Full Name: Hypocretin Receptor 2

Genomic Location: Chromosome 6:55,106,460-55,282,620

Protein Size: 444 amino acids


The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A.

Linked SNP(s):

  • rs35833281 is linked to HCRTR2, it is located in the first intron.
  • Population frequencies are approximately 86% for the reference allele (G) and 14% for the alternate allele (C).
  • Studies suggest the C allele is associated with being a morning person.
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