Full Name: Hypocretin Receptor 2
Genomic Location: Chromosome 6:55,106,460-55,282,620
Protein Size: 444 amino acids
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A.
- rs35833281 is linked to HCRTR2, it is located in the first intron.
- Population frequencies are approximately 86% for the reference allele (G) and 14% for the alternate allele (C).
- Studies suggest the C allele is associated with being a morning person.