Full Name: 5-Hydroxytryptamine Receptor 1A

Genomic Location: Chromosome 5:63,960,048-63,962,507

Protein Size: 422 amino acids


G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signalling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signalling via G proteins and mediate activation of alternative signalling pathways. Signalling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behaviour. Plays a role in the response to anxiogenic stimuli

Linked SNP(s):

  • rs6295 is linked to HTR1A, it is located approximately 500 bases downstream.
  • Population frequencies are approximately 51% for the reference allele (C) and 49% for the alternate allele (G).
  • Studies suggest the G allele is associated with increased anxiety and impulsivity.
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