Full Name: Leucine Rich Repeat Containing 14
Genomic Location: Chromosome 8:144,517,965-144,525,178
Protein Size: 493 amino acids
This gene encodes a leucine-rich repeat-containing protein. It negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB.
- rs2721173 is linked to LRRC14, it is located in an intronic region.
- Population frequencies are approximately 57% for the reference allele (C) and 43% for the alternate allele (T).
- Studies suggest the T allele is associated with reduced school years and cognitive performance.