LRRC14

Full Name: Leucine Rich Repeat Containing 14

Genomic Location: Chromosome 8:144,517,965-144,525,178

Protein Size: 493 amino acids

Function:

This gene encodes a leucine-rich repeat-containing protein. It negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB.

Linked SNP(s):

  • rs2721173 is linked to LRRC14, it is located in an intronic region.
  • Population frequencies are approximately 57% for the reference allele (C) and 43% for the alternate allele (T).
  • Studies suggest the T allele is associated with reduced school years and cognitive performance.
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