LRRN2

Full Name: Leucine Rich Repeat Neuronal 2

Genomic Location: Chromosome 1:204,617,170-204,685,738

Protein Size: 713 amino acids

Function:

The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas.

Linked SNP(s):

  • rs11584700 is linked to LRRN2, it is located about 9,500 bases upstream.
  • Population frequencies are approximately 82% for the reference allele (A) and 18% for the alternate allele (G).
  • Studies suggest the G allele is associated with higher educational attainment.
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