Full Name: Leucine Rich Repeat Neuronal 2
Genomic Location: Chromosome 1:204,617,170-204,685,738
Protein Size: 713 amino acids
The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas.
- rs11584700 is linked to LRRN2, it is located about 9,500 bases upstream.
- Population frequencies are approximately 82% for the reference allele (A) and 18% for the alternate allele (G).
- Studies suggest the G allele is associated with higher educational attainment.