MIR2113

Full Name: MicroRNA 2113 

Genomic Location: Chromosome 6:98,024,531-98,024,621

Protein Size: NA 

Function:

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA.

Linked SNP(s):

  • rs10457441 is linked to MIR2113, it is located approximately 100,000 bases upstream.
  • Population frequencies are approximately 58% for the reference allele (T) and 42% for the alternate allele (C).
  • Studies suggest the T allele is associated with very slightly reduced cognition.
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