Full Name: Nitric Oxide Synthase 3
Genomic Location: Chromosome 7:150,991,017-151,014,599
Protein Size: 1203 amino acids
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm.
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
- rs1799983 is linked to NOS3, it is located in the protein coding region.
- Population frequencies are approximately 25% for the reference allele (T) and 75% for the alternate allele (G).
- Studies suggest the T allele is associated with hypertension, but adopting a healthy diet (increased omega-3) can help reduce risk.