Full Name: Nuclear Factor, Erythroid 2 Like 2

Genomic Location: Chromosome 2:177,227,595-177,392,697

Protein Size: 605 amino acids


Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress and the regulation of cellular redox conditions. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.

This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals.

Linked SNP(s):

  • rs7181866 is supposedly linked to NRF2.
  • Population frequencies are approximately 93% for the reference allele (A) and 7% for the alternate allele (G).
  • Studies suggest the G allele is associated with endurance athletes.
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