PER2

Full Name: Period Circadian Regulator 2

Genomic Location: Chromosome 2:238,244,038-238,290,102 

Protein Size: 1255 amino acids

Function:

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders.

Linked SNP(s):

  • rs35333999 is linked to PER2, it is located in the protein coding region.
  • Population frequencies are approximately 97% for the reference allele (C) and 3% for the alternate allele (T).
  • Studies suggest the T allele is associated with a preference for longer days and later nights.

  • rs934945 is linked to PER2, it is located in the protein coding region.
  • Population frequencies are approximately 80% for the reference allele (G) and 20% for the alternate allele (A).
  • Studies suggest the G allele is associated with morningness, while the A allele is associated with reduced sleep quality.

  • rs55694368 is linked to PER2, it is located approximately 100,000 bases downstream.
  • Population frequencies are approximately 93% for the reference allele (G) and 7% for the alternate allele (T).
  • Studies suggest the T allele is associated with a reduced likelihood of being a morning person.
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