PER3

Full Name: Period Circadian Regulator 3

Genomic Location: Chromosome 1:7,784,320-7,845,181

Protein Size: 1201 amino acids

Function:

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been linked to sleep disorders.

Linked SNP(s):

  • rs228697 is linked to PER3, it is located in the protein coding region.
  • Population frequencies are approximately 92% for the reference allele (C) and 8% for the alternate allele (G).
  • Studies suggest the G allele is associated with increased anxiety and a preference for evening chronotypes.

  • rs11121022 is linked to PER3, it is located about 8,000 bases upstream.
  • Population frequencies are approximately 64% for the reference allele (A) and 36% for the alternate allele (C).
  • Studies suggest the C allele is associated with being a morning bird.

  • rs2640909 is linked to PER3, it is located in the protein coding region.
  • Population frequencies are approximately 85% for the reference allele (T) and 15% for the alternate allele (C).
  • Studies suggest the C allele is associated with being a morning bird.

  • rs10462021 is linked to PER3, it is located in the protein coding region.
  • Population frequencies are approximately 83% for the reference allele (A) and 17% for the alternate allele (G).
  • Studies suggest the G allele is associated with delayed sleep rhythms.
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