PPARG

Full Name: Peroxisome Proliferator Activated Receptor Gamma

Genomic Location: Chromosome 3:12,287,368-12,471,013

Protein Size: 505 amino acids

Function:

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer.

Linked SNP(s):

  • rs1801282 is linked to PPARG, it is located in a complicated alternate splice region.
  • Population frequencies are approximately 89% for the reference allele (C) and 11% for the alternate allele (G).
  • Studies suggest the G allele is associated with gains from resistance training and improved health outcomes with training, while the C allele is associated with a higher risk for BMI that is mitigated through a healthy diet.
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