RGS2

Full Name: Regulator Of G Protein Signaling 2

Genomic Location: Chromosome 1:192,809,039-192,812,277 

Protein Size: 211 amino acids

Function:

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis.

Linked SNP(s):

  • rs4606 is linked to RGS2, it is located in the 3’-UTR region.
  • Population frequencies are approximately 70% for the reference allele (C) and 30% for the alternate allele (G).
  • Studies suggest the G allele is associated with increased resilience following trauma (hurricane).
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