Full Name: Solute Carrier Family 6 Member 4

Genomic Location: Chromosome 17:30,194,319-30,236,002

Protein Size: 630 amino acids


This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.

Linked SNP(s):

  • rs140701 is linked to SLC6A4, it is located within an intronic region.
  • Population frequencies are approximately 59% for the reference allele (G) and 41% for the alternate allele (A).
  • Studies suggest the A allele is associated with an increased association with anxiety and panic disorder.
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