SLC6A4

Full Name: Solute Carrier Family 6 Member 4

Genomic Location: Chromosome 17:30,194,319-30,236,002

Protein Size: 630 amino acids

Function:

This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.

Linked SNP(s):

  • rs140701 is linked to SLC6A4, it is located within an intronic region.
  • Population frequencies are approximately 59% for the reference allele (G) and 41% for the alternate allele (A).
  • Studies suggest the A allele is associated with an increased association with anxiety and panic disorder.
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