Full Name: Transcription Factor 7 Like 2

Genomic Location: Chromosome 10:112,950,219-113,167,678

Protein Size: 619 amino acids


This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis.

Linked SNP(s):

  • rs7903146 is linked to TCF7L2, it is located within an intronic region.
  • Population frequencies are approximately 74% for the reference allele (C) and 26% for the alternate allele (T).
  • Studies suggest the T allele is associated with an increased risk for diabetes that can be mitigated through a healthy diet.
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