Full Name: Transcobalamin 2

Genomic Location: Chromosome 22:30,606,838-30,627,278

Protein Size: 427 amino acids


This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene.

Linked SNP(s):

  • rs1801198 is linked to TCN2, it is located in the protein coding region.
  • Population frequencies are approximately 43% for the reference allele (G) and 57% for the alternate allele (C).
  • Studies suggest the G allele is associated with higher homocysteine levels.
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