TRHR

Full Name: Thyrotropin Releasing Hormone Receptor

Genomic Location: Chromosome 8:109,086,342-109,119,584

Protein Size: 398 amino acids

Function:

This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance.

Linked SNP(s):

  • rs16892496 is linked to TRHR, it is located within the single intron.
  • Population frequencies are approximately 69% for the reference allele (A) and 31% for the alternate allele (C).
  • Studies suggest the A allele is associated with increased muscle strength and mass.
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