Full Name: Thyrotropin Releasing Hormone Receptor
Genomic Location: Chromosome 8:109,086,342-109,119,584
Protein Size: 398 amino acids
This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance.
- rs16892496 is linked to TRHR, it is located within the single intron.
- Population frequencies are approximately 69% for the reference allele (A) and 31% for the alternate allele (C).
- Studies suggest the A allele is associated with increased muscle strength and mass.