VRK2

Full Name: VRK Serine/Threonine Kinase 2 

Genomic Location: Chromosome 2:57,907,629-58,159,920

Protein Size: 508 amino acids

Function:

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia.

Linked SNP(s):

  • rs17190618 is linked to VRK2, it is located approximately 490,000 bases upstream.
  • Population frequencies are approximately 90% for the reference allele (A) and 10% for the alternate allele (T).
  • Studies suggest the A allele is associated with slightly reduced sleep duration.
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